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Unsupervised clustering techniques have been widely applied to flow simulation data to alleviate clutter and occlusion in the resulting visualization. However, there is an absence of systematic guidelines for users to evaluate (both quantitatively and visually) the appropriate clustering technique and similarity measures for streamline and pathline curves. In this work, we provide an overview of a number of prevailing curve clustering techniques. We then perform a comprehensive experimental study to qualitatively and quantitatively compare these clustering techniques coupled with popular similarity measures used in the flow visualization literature. Based on our experimental results, we derive empirical guidelines for selecting the appropriate clustering technique and similarity measure given the requirements of the visualization task. We believe our work will inform the task of generating meaningful reduced representations for large-scale flow data and inspire the continuous investigation of a more refined guidance on clustering technique selection.